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Treatment of MEK inhibitor-induced paronychia with doxycycline

Qisi Sun1, Richard J Antaya1,2

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.

Pediatric Dermatology
|July 10, 2020
PubMed

A 12-year-old girl with neurofibromatosis type 1 and a large facial plexiform neurofibroma had been participating in a selumetinib clinical trial for the past 5 years. Despite decreased tumor size, she developed recalcitrant selumetinib-induced paronychia. Various antibiotics, topical medications, and surgeries were only minimally effective. Full-dose doxycycline resolved the paronychia, and sub-antimicrobial dosing has prevented recurrences for several months, permitting her to continue her selumetinib course.

Keywords:
MEK inhibitorNF1doxycyclineneurofibromatosisparonychiaselumetinib

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