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Differences in hair cortisol concentrations and reported anxiety in women with preeclampsia versus uncomplicated

Joris J A van Esch1, Antoinette C Bolte1, Frank P H A Vandenbussche1

  • 1Radboud University Medical Center, Department of Obstetrics and Gynecology, P.O. Box 9101, Post 791, 6500 HB Nijmegen, The Netherlands.

Pregnancy Hypertension
|July 10, 2020
PubMed

This Dutch multicenter case-controlled study investigated whether cortisol concentrations and psychosocial stress during pregnancy differed between women with early-onset preeclampsia, late-onset preeclampsia, and uncomplicated pregnancies. Cortisol concentrations were analyzed in three hair segments representing the preconception period, first, and second trimester of pregnancy. Cortisol trajectories differed, with early-onset preeclampsia showing steeper increases in cortisol and higher cortisol concentrations during the second trimester. Reported anxiety in women with preeclampsia was higher compared to women with uncomplicated pregnancies. These results indicate that measures of cortisol and reported anxiety differ between early-onset, late-onset preeclampsia, and uncomplicated pregnancies.

Keywords:
AnxietyEarly-onset preeclampsiaHair cortisolLate-onset preeclampsiaPsychosocial stress

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