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Related Experiment Videos

Ankylosing spondylitis and multiple sclerosis: an apparent association?

P S Hanrahan1, A S Russell, D R McLean

  • 1Rheumatic Disease Unit, University of Alberta, Edmonton, Canada.

The Journal of Rheumatology
|October 1, 1988
PubMed
Summary

This study investigated the link between ankylosing spondylitis (AS) and multiple sclerosis (MS). While a potential association exists, findings suggest AS does not commonly present with a subclinical MS-like syndrome.

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Area of Science:

  • Neurology
  • Rheumatology
  • Immunogenetics

Background:

  • The Human Leukocyte Antigen B27 (HLA-B27) gene is strongly associated with ankylosing spondylitis (AS).
  • Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system.
  • The potential co-occurrence and shared genetic factors between AS and MS warrant investigation.

Purpose of the Study:

  • To determine the prevalence of HLA-B27 in patients with multiple sclerosis (MS).
  • To investigate the presence of ankylosing spondylitis (AS) in HLA-B27 positive MS patients.
  • To assess for subclinical MS-like neurological abnormalities in patients with AS using evoked potential studies.

Main Methods:

  • Cross-sectional study of 420 MS patients to determine HLA-B27 prevalence.

Related Experiment Videos

  • Clinical and radiological assessment of HLA-B27 positive MS patients for AS.
  • Evoked potential studies (BAEP, VEP, SSEP) in 16 AS patients.

    • Main Results:

    • HLA-B27 prevalence in MS patients was 10.2%.
    • AS was diagnosed in 12-25% of HLA-B27 positive MS patients.
    • Evoked potential studies in AS patients showed minor abnormalities, primarily peripheral, with one case developing MS.

    Conclusions:

    • A potential association between AS and MS is suggested by the data.
    • The study refutes a frequent subclinical MS-like syndrome in AS patients.
    • Evoked potential studies in AS patients are unlikely to be confused with MS findings.