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Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

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Heat Diffusion Kernel Algorithm-Based Interpretation of the Disease Intervention Mechanism for DHA.

Yuan Quan^1,2, Hong-Yu Zhang³, Jiang-Hui Xiong²

¹Harbin Institute of Technology Shenzhen Graduate School, Shenzhen 518055, China.

|July 11, 2020

Summary

This summary is machine-generated.

Docosahexaenoic acid (DHA) impacts complex diseases by regulating gene networks. This study reveals DHA

Area of Science:

Genomics and Systems Biology
Nutritional Science and Molecular Mechanisms

Background:

Docosahexaenoic acid (DHA) shows efficacy in preventing and treating cancer, congenital disorders, and chronic diseases.

Keywords:

complex disease intervention docosahexaenoic acid (DHA)gene expression profiles heat diffusion kernel algorithm mechanism interpretation

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Complex diseases are linked to disordered gene regulatory networks, as suggested by the omnigenic hypothesis.

Previous research on DHA's disease intervention mechanisms focused on individual genes or pathways, yielding inconsistent results.