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Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Updated: Jun 25, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

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Metabolome Changes in Cerebral Ischemia.

Tae Hwan Shin¹, Da Yeon Lee¹, Shaherin Basith¹

¹Department of Physiology, Ajou University School of Medicine, Suwon 16499, Korea.

|July 11, 2020

Summary

Cerebral ischemia, or stroke, involves complex brain cell damage. Studying metabolic changes offers new insights into stroke pathology and potential biomarkers for diagnosis and treatment.

Keywords:

cerebral ischemia metabolic network metabolomics middle cerebral artery occlusion oxygen-glucose deprivation

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Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

Area of Science:

Neuroscience
Biochemistry
Pathology

Background:

Cerebral ischemia causes brain damage, neuronal cell death, and stroke, leading to significant global morbidity and mortality.
Existing research on ischemic stroke mechanisms involves various molecular aspects but has not fully elucidated metabolic and cellular pathologies.
The complexity and heterogeneity of ischemic stroke make establishing relationships among pathological mechanisms challenging.

Purpose of the Study:

To review metabolic and cellular changes in cerebral ischemia.
To deepen the understanding of the pathology underlying ischemic strokes.
To contribute to the development of novel diagnostic and therapeutic strategies for ischemic stroke.

Main Methods:

Review of existing investigations on metabolic changes in cerebral ischemia.
Analysis of metabolic changes (amino acids, organic acids, polyamines) in an in vivo rat model.
Application of bioinformatics tools to identify relationships between metabolic alterations and cellular functions.

Main Results:

Metabolome-based techniques provide insights into cellular pathologic status by reflecting metabolic disturbances.
Previous analyses identified relationships between metabolic changes and cellular functions in a rat model of cerebral ischemia.
This review synthesizes current knowledge on metabolic and cellular alterations in cerebral ischemia.

Conclusions:

Metabolic and cellular pathologies are central to cerebral ischemia and ischemic stroke.
Understanding these changes is crucial for developing effective diagnostic and therapeutic interventions.
Further research into the metabolome of ischemic brain injury can yield valuable biomarkers and treatment targets.