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Updated: Dec 15, 2025
Murine Kidney Transplant Technique
Published on: October 20, 2015
Cytomegalovirus Experience in Pediatric Kidney Transplantation in 26 Years' Time
Ahmet Keskinoglu1, İpek Kaplan Bulut1, Sevgin Taner1
1Department of Pediatric Nephrology, Ege University Faculty of Medicine Children's Hospital, Bornova-İzmir, Turkey.
Insights
Cytomegalovirus (CMV) infection was found in one-fifth of pediatric kidney transplant patients, primarily within the first six months post-transplant. Effective treatment mitigated CMV
Area of Science:
- Nephrology
- Pediatric Nephrology
- Transplant Immunology
Background:
- Kidney transplantation in children is susceptible to cytomegalovirus (CMV) infection.
- Investigating CMV's impact on kidney graft function and patient outcomes is crucial.
Purpose of the Study:
- To determine the prevalence of CMV infection in pediatric kidney transplant recipients.
- To identify risk factors associated with CMV infection.
- To evaluate the effect of CMV infection on kidney dysfunction, rejection, and survival.
Main Methods:
- Retrospective analysis of 135 pediatric renal transplant patients.
- Evaluation of CMV infection status, CMV risk stratification (D+/R-), and clinical data.
- Identification of risk factors for CMV infection and graft outcomes.
Main Results:
- CMV infection identified in 20% of patients, with most cases occurring within 6 months.
- High-risk CMV status (D+R-) was observed in 40.9% of infected patients.
- Risk factors included cold ischemia time, male sex, deceased donor, HLA-mismatches, and antithymocyte globulin dose.
- Acute rejection/graft failure occurred in 27% of patients.
- CMV infection did not significantly impact rejection, graft failure, or survival with effective treatment.
Conclusions:
- CMV infection frequency and risk factors align with existing literature in pediatric kidney transplant recipients.
- Despite significant rejection rates, CMV infection did not adversely affect graft outcomes or survival when managed effectively.
Introduction:
In this study,we investigated the presence of cytomegalovirus (CMV) infection in kidney transplanted children and its effect on kidney dysfunction.
Material And Methods:
One hundred thirty-five pediatric renal transplant patients were included in this study. The presence of CMV infection, CMV risk status, and other clinical features of the patients were evaluated retrospectively.
Results:
Fifty-three percent of all patients and 68.8% of patients with CMV were male. The mean age was 12 years in all patients and CMV groups. According to the CMV risk classification, 40.9% of the patients with CMV infection/disease were in the high-risk group (CMV D+R-). In CMV risk groups, the presence of CMV infection/disease was similar. Cold ischemia time, male sex (patients and donors), deceased donor, higher HLA-mismatches, and cumulative antithymocyte globulin dose were found as risk factors for CMV infection/disease. Acute rejection/graft failure was observed in 27% of all patients. CMV infection has no effect on rejection/graft failure and survival.
Discussion:
The frequency and risk factors of CMV in renal transplant children in our study were consistent with the literature.
Conclusions:
CMV infection was found in one-fifth of our patients and the majority (71.9%) of them developed infection in the first 6 months. In one-third of our patients acute rejection/graft failure was observed. There was no effect of CMV infection on rejection/graft failure and survival in pediatric patients with proper and effective treatment.
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