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Comparison of DCE-MRI parametric mapping using MP2RAGE and variable flip angle T1 mapping.

Robert V Bergen1, Lawrence Ryner1, Marco Essig2

  • 1Department of Physics & Astronomy, University of Manitoba, Canada; Medical Physics, CancerCare Manitoba, Canada.

Magnetic Resonance Imaging
|July 11, 2020
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Summary
This summary is machine-generated.

Accurate T1 mapping is crucial for quantitative DCE-MRI. The MP2RAGE sequence provides more accurate T1 maps than VFA, improving pharmacokinetic modeling and lesion characterization in prostate cancer.

Keywords:
DCE-MRIK(trans)MP2RAGEPerfusionQuantitativeT(1) mapping

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Area of Science:

  • Medical Imaging
  • Magnetic Resonance Imaging
  • Quantitative Imaging

Background:

  • Quantitative dynamic contrast-enhanced MRI (DCE-MRI) relies on pharmacokinetic models sensitive to T1 mapping accuracy.
  • Accurate T1 mapping is essential for reliable DCE-MRI studies and accurate Ktrans parameter estimation.
  • Conventional variable flip angle (VFA) T1 mapping may introduce inaccuracies.

Purpose of the Study:

  • Compare the accuracy of Magnetization Prepared Rapid (two) Gradient Echo (MP2RAGE) T1 mapping against the conventional VFA approach.
  • Evaluate the impact of MP2RAGE T1 mapping on the Ktrans parameter in DCE-MRI.
  • Assess the potential for improved lesion characterization and clinical outcomes.

Main Methods:

  • Phantom and in vivo (prostate) studies were conducted comparing VFA and MP2RAGE T1 mapping against the gold standard inverse recovery (IR) method.
  • Regions of interest (ROIs) were manually drawn over phantoms and prostate tissues/lesions.
  • Ktrans maps were calculated using the extended Tofts model based on T1 values from both methods.

Main Results:

  • VFA T1 maps overestimated T1 values by up to 50% compared to IR in phantoms, while MP2RAGE differed by only up to 9%.
  • Significant differences were observed in MP2RAGE-derived T1 and Ktrans values compared to VFA values in prostatic lesions (p < 0.05).
  • VFA consistently underestimated Ktrans compared to MP2RAGE (p < 0.05).

Conclusions:

  • MP2RAGE T1 mapping demonstrates superior accuracy compared to VFA, leading to more reliable pharmacokinetic modeling.
  • The improved accuracy of MP2RAGE T1 maps can enhance the characterization of prostatic lesions.
  • This advancement holds potential for improving clinical outcomes in DCE-MRI studies.