Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phagocytosis00:41

Phagocytosis

7.4K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
7.4K
Phagocytosis00:41

Phagocytosis

92.0K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
92.0K
Maturation of Endosomes01:28

Maturation of Endosomes

5.4K
The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
5.4K
Recycling Endosomes and Transcytosis00:58

Recycling Endosomes and Transcytosis

3.3K
The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
3.3K
Porin Insertion in the Outer Mitochondrial Membrane01:12

Porin Insertion in the Outer Mitochondrial Membrane

4.1K
Porins are beta-barrel proteins translocated to the mitochondrial outer membrane through the TOM complex into the intermembrane space. Porin precursors bind TIM chaperones within the intermembrane space and are guided to the Sorting and Assembly Machinery complex or SAM complex on the outer mitochondrial membrane.
Three models describe the assembly of porins by the SAM complex and their insertion into the outer membrane. Model 1 suggests that porins are assembled outside the SAM channel as the...
4.1K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.0K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionarily conserved short linear motifs drive actin filament binding.

Nature cell biology·2026
Same author

Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages.

Cell reports·2026
Same author

Myosins 1e/f at the podosome base regulate podosome dynamics and promote macrophage migration.

European journal of cell biology·2025
Same author

Editorial: Understanding the mechanism of dynamic cell communications: a much needed angle for cell motility and barrier functions.

Frontiers in molecular biosciences·2025
Same author

Introduction to special issue on 'Microscopy Techniques'.

Journal of microscopy·2025
Same author

Predictive factors for long-term patency in duodenal stenting for malignant gastric outlet obstruction.

Endoscopy international open·2025

Related Experiment Video

Updated: Dec 15, 2025

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies
08:52

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

2.9K

The podosome cap: past, present, perspective.

Stefan Linder1, Pasquale Cervero1

  • 1Institut Für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

European Journal of Cell Biology
|July 11, 2020
PubMed
Summary
This summary is machine-generated.

Podosomes are actin-based cell structures with complex roles. This study details the podosome cap, revealing it as a multilayered module crucial for regulating actomyosin contractility and podosome function.

Keywords:
ActinActin-Binding proteinsContractilityMyosinPodosomePodosome cap

More Related Videos

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions
10:50

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions

Published on: April 3, 2014

10.6K
Protrusion Force Microscopy: A Method to Quantify Forces Developed by Cell Protrusions
06:37

Protrusion Force Microscopy: A Method to Quantify Forces Developed by Cell Protrusions

Published on: June 16, 2018

5.9K

Related Experiment Videos

Last Updated: Dec 15, 2025

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies
08:52

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

2.9K
Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions
10:50

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions

Published on: April 3, 2014

10.6K
Protrusion Force Microscopy: A Method to Quantify Forces Developed by Cell Protrusions
06:37

Protrusion Force Microscopy: A Method to Quantify Forces Developed by Cell Protrusions

Published on: June 16, 2018

5.9K

Area of Science:

  • Cell Biology
  • Biochemistry
  • Cytoskeleton Dynamics

Background:

  • Podosomes are actin-rich adhesion structures essential for cellular functions.
  • Their complex architecture necessitates intricate spatiotemporal regulation.
  • The classical podosome model has been expanded to include substructures like the podosome cap.

Purpose of the Study:

  • To discuss known components of the podosome cap.
  • To explore their regulatory roles in podosome turnover and function.
  • To propose a new model for the podosome cap's function.

Main Methods:

  • Literature review of podosome cap components and their discovery.
  • Analysis of potential regulatory mechanisms.
  • Development of a new conceptual model for the podosome cap.

Main Results:

  • The podosome cap comprises numerous components with specific functions.
  • These components are involved in regulating podosome dynamics.
  • A new model presents the podosome cap as a multilayered module fine-tuning actomyosin contractility.

Conclusions:

  • The podosome cap is a critical regulatory module.
  • It plays a key role in fine-tuning actomyosin contractility for podosome architecture and function.
  • Further research can identify additional cap components and elucidate their roles.