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Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases

Maryam Rashidi1, Ian P Wicks1, James E Vince1

  • 1The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.

Trends in Molecular Medicine
|July 11, 2020
PubMed

Insights

Cellular and environmental microparticles trigger inflammation and disease by activating inflammasome signaling pathways. Targeting these pathways offers potential treatments for various inflammatory disorders.

Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Microparticle accumulation is implicated in numerous inflammatory diseases affecting joints, lungs, kidneys, cardiovascular system, and brain.
  • A conserved inflammasome signaling pathway activated by microparticles has recently been identified.

Purpose of the Study:

  • To review disease-promoting microparticles and their mechanisms of inflammasome activation.
  • To highlight the unique nature of microparticle-induced inflammasome responses.
  • To discuss therapeutic strategies targeting inflammasomes for microparticle-driven diseases.

Main Methods:

  • Literature review of microparticle-induced inflammasome activation.
  • Analysis of mechanisms triggering inflammasome complexes and interleukin-1β (IL-1β) generation.
  • Examination of inflammasome and cell death responses.

Main Results:

  • Microparticles activate inflammasome complexes, leading to IL-1β production and cell death.
  • Microparticle-induced inflammasome activation differs from canonical activators.
  • These pathways are crucial in various inflammatory conditions.

Conclusions:

  • Microparticles are significant initiators of inflammatory diseases via inflammasome activation.
  • Understanding these mechanisms is key to developing novel therapies.
  • Targeting inflammasomes presents a promising therapeutic avenue for microparticle-related diseases.
Keywords:
NLRP3atherosclerosisinflammasomenecroptosisneuroinflammationpyroptosis

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