Related Experiment Video
Updated: Dec 15, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from
Kazuyuki Sato1, Akira Kawasaki1, Yukiko Karuo1
1Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Abstract:
Fluorescent molecules based on a fluorinated isoxazole scaffold were synthesized and investigated for their photochemical properties. The introduction of a fluorine substituent into 3,5-diarylisoxazoles led to an increase of fluorescence intensity and exhibited a redshift in the emission intensity. α-Fluorinated boron ketoiminates (F-BKIs) were also synthesized via a ring-opening reaction of 4-fluoroisoxazoles and exhibited highly fluorescent luminescence and aggregation-induced emission (AIE), showing promise as a new fluorophore.
Related Concept Videos
Variables Affecting Phosphorescence and Fluorescence
Super-resolution Fluorescence Microscopy
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Immunofluorescence Microscopy
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

