OXY-SCORE: a new perspective for left ventricular hypertrophy diagnosis

Area of Science:

• Cardiology
• Biochemistry
• Biomarkers

Background:

• Oxidative stress is implicated in various pathologies.
• A global oxidative stress indicator (OXY-SCORE) exists but lacks validation in left ventricular hypertrophy (LVH).
• LVH requires a specific, validated indicator for oxidative stress assessment.

Purpose of the Study:

• To design and calculate a plasma oxidative stress global index (OXY-SCORE) specifically for patients with LVH.
• To assess the utility of this OXY-SCORE in differentiating LVH patients from controls.
• To evaluate the OXY-SCORE's association with LVH, independent of other clinical factors.

Main Methods:

• Recruited 70 adult patients, divided into control and LVH groups based on echocardiography.
• Measured plasma biomarkers of oxidative damage and antioxidant capacity.
• Calculated the OXY-SCORE using spectrophotometry/fluorimetry.

Main Results:

• OXY-SCORE showed a highly significant difference between LVH and control groups (p < 0.001).
• The OXY-SCORE achieved 68.6% sensitivity and 68.6% specificity for LVH screening at a cut-off of -1.
• A multivariable logistic regression confirmed a significant positive association between OXY-SCORE and LVH (OR=0.55, p=0.001), independent of confounders.

Conclusions:

• The developed OXY-SCORE is a promising tool for aiding LVH diagnosis.
• OXY-SCORE may also serve as a valuable indicator for monitoring treatment response in LVH patients.