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Updated: Dec 15, 2025

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The role of GPR110 in lung cancer progression

Benting Ma1, Junjie Zhu2, Jieakesu Su1

  • 1Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.

Annals of Translational Medicine
|July 11, 2020
PubMed
Abstract

Insights

G protein-coupled receptor 110 (GPR110) promotes lung cancer progression. This study found GPR110 enhances tumor cell proliferation and migration, indicating its role in oncogenesis.

Area of Science:

  • Oncology
  • Molecular Biology
  • G protein-coupled receptors (GPCRs)

Background:

  • GPCRs play roles in signaling pathways, but their involvement in cancer oncogenesis and progression is not fully understood.
  • Previous research indicated Gpr110 absence decelerates liver fibrotic tumor development.
  • This study investigates the role of GPR110 in lung cancer oncogenesis and progression.

Purpose of the Study:

  • To investigate the role of GPR110 in lung cancer development.
  • To analyze the effect of GPR110 on lung cancer cell proliferation and migration.

Main Methods:

  • GPR110 expression analyzed in patient lung tumor tissues using Western blotting and real-time PCR.
  • Cell proliferation, migration, and aggregation assessed using CCK8, wound healing, and Transwell assays.
  • Nude mouse xenograft and urethane-induced lung cancer models used to evaluate tumor development.

Main Results:

  • GPR110 mRNA and protein expression significantly elevated in lung cancer tissues compared to normal tissues.
  • Overexpression of GPR110 promoted proliferation, aggregation, and migration of lung cancer cells (H1299).
  • GPR110 overexpression significantly enhanced tumor development in nude mice xenograft models.

Conclusions:

  • GPR110 expression is significantly higher in lung cancer tissues.
  • GPR110 promotes lung cancer progression by accelerating cell proliferation and migration.
  • GPR110 is a potential therapeutic target for lung cancer treatment.
Keywords:
Gpr110Xenograft modellung cancerurethane

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