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Aortic thrombus in patients with severe COVID-19: review of three cases

María de Carranza1, Danilo-Eduardo Salazar2, Jesús Troya3

  • 1Department of Internal Medicine, Hospital Universitario Infanta Leonor, Infanta Leonor, University Hospital, Avenida Gran Vía Este 80, 28031, Madrid, Spain. mariadecarranzalopez@gmail.com.

Journal of Thrombosis and Thrombolysis
|July 11, 2020
PubMed

Insights

Severe COVID-19 can cause blood clots in unusual places, including the aorta. This study highlights three cases of aortic thrombosis in patients with SARS-CoV-2 infection, emphasizing the virus's pro-coagulant effects.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Hematology

Background:

  • Coronavirus disease 2019 (COVID-19) is linked to an increased risk of both venous and arterial thromboembolism.
  • Severe COVID-19 can trigger an exaggerated immune response, contributing to a pro-coagulant state.
  • Thrombosis in atypical locations, such as the aorta, is a rare but serious complication associated with SARS-CoV-2 infection.

Observation:

  • This report details three cases of patients with confirmed SARS-CoV-2 infection who developed aortic thrombi.
  • Diagnosis of aortic clots was established using computed tomography (CT) angiography.
  • These cases underscore the potential for COVID-19 to induce thrombosis in unusual vascular sites.

Findings:

  • COVID-19 predisposes patients to thromboembolic events, including rare aortic clots.
  • Severe coagulation abnormalities in SARS-CoV-2 patients warrant consideration for thrombosis in atypical locations.
  • The pro-coagulant nature of COVID-19 contributes to the occurrence of aortic thrombosis.

Implications:

  • Clinicians should consider aortic thrombosis in SARS-CoV-2 infected patients presenting with severe coagulation derangements.
  • Early recognition and management of atypical thrombosis are crucial for improving outcomes in severe COVID-19.
  • This finding expands the understanding of vascular complications associated with SARS-CoV-2 infection.

Keywords:
Aortic thrombiCOVID-19Severe pneumonia

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