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Apelin Receptor Signaling During Mesoderm Development.

Derya Sağraç1, Hatice Burcu Şişli1, Ayşegül Doğan2

  • 1Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.

Advances in Experimental Medicine and Biology
|July 11, 2020
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The Apelin receptor (Aplnr) is vital for embryonic development, particularly cardiac function. Understanding its signaling pathways can illuminate developmental processes and adult diseases.

Keywords:
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Area of Science:

  • Developmental Biology
  • Cardiovascular Biology
  • Molecular Signaling

Background:

  • The Apelin receptor (Aplnr), a G-protein coupled receptor, plays diverse physiological roles in adults, including homeostasis and cardiovascular function.
  • Aplnr signaling involves peptides like Apelin and Elabela, which have different active isoforms.
  • Dysregulation of Aplnr signaling is implicated in adult pathologies such as obesity, heart disease, and cancer.

Purpose of the Study:

  • To investigate the crucial developmental role of Aplnr signaling in mammalian embryogenesis.
  • To elucidate the underlying molecular mechanisms governing Aplnr's function during embryonic development.
  • To explore the link between embryonic Aplnr function and adult cardiovascular health and disease.

Main Methods:

  • Analysis of Aplnr signaling components during mammalian embryonic development.
  • Investigation of Aplnr's role in cell migration, proliferation, and differentiation.
  • Study of cardiac progenitor cell migration and cardiac function in Aplnr mutants.

Main Results:

  • Aplnr signaling is essential for the migration of cardiac progenitors and proper cardiac development.
  • Mutations in Aplnr signaling components lead to severe cardiac malformations, developmental defects, and lethality.
  • Aplnr signaling influences the movement of mesodermal cells and endodermal precursors.

Conclusions:

  • Aplnr signaling is critical for mammalian embryonic development, especially for cardiac formation and function.
  • Understanding embryonic Aplnr mechanisms offers insights into adult tissue function and disease pathology.
  • Further research into Aplnr signaling can reveal fundamental regulatory mechanisms in development and disease.