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Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

251
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
251
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

199
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
199
Mitral Regurgitation IV: Nursing Management01:28

Mitral Regurgitation IV: Nursing Management

230
Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...
230
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

179
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
179
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

221
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
221
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

131
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
131

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Related Experiment Video

Updated: Dec 15, 2025

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

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Functional mitral regurgitation.

Federico M Asch1, Diego Medvedofsky

  • 1MedStar Health Research Institute and MedStar Washington Hospital Center, Washington, District of Columbia, USA.

Current Opinion in Cardiology
|July 11, 2020
PubMed
Summary
This summary is machine-generated.

Functional mitral regurgitation (FMR) treatment with transcatheter mitral valve repair (TMVr) shows varied results. Careful patient selection is key for TMVr to benefit heart failure patients with FMR.

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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
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A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Heart Valve Disease

Background:

  • Functional mitral regurgitation (FMR) is linked to cardiomyopathy, heart failure, and increased mortality.
  • Transcatheter mitral valve repair (TMVr) offers a new therapeutic avenue for select FMR patients.
  • Optimal medical and device therapy requires precise candidate selection for TMVr.

Purpose of the Study:

  • To review FMR mechanisms and echocardiographic assessment.
  • To discuss recent studies on transcatheter mitral valve repair (TMVr) for FMR.
  • To analyze the impact of patient selection on TMVr outcomes.

Main Methods:

  • Review of current literature on functional mitral regurgitation.
  • Analysis of two major randomized controlled trials: MITRA-FR and COAPT.
  • Comparison of patient enrollment criteria and outcomes between trials.

Main Results:

  • The MITRA-FR trial showed no clinical benefit of TMVr with MitraClip.
  • The COAPT trial demonstrated significant clinical and echocardiographic benefits of TMVr with MitraClip.
  • Discrepant trial results may stem from differences in patient selection criteria.

Conclusions:

  • Transcatheter mitral valve repair (TMVr) can benefit carefully selected FMR patients on optimal medical therapy.
  • Understanding patient selection criteria is crucial for successful TMVr outcomes.
  • Future studies and clinical practice will be influenced by these trial findings.