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The pharmacological management of malignant hypertension

Philippe Gosse1, Romain Boulestreau2, Camille Brockers1

  • 1Hypertension Unit, University Hospital of Bordeaux, Hôpital Saint André, Bordeaux.

Journal of Hypertension
|July 11, 2020
PubMed

Insights

Malignant hypertension (MHT) requires prompt recognition and treatment. While modern agents have advanced care, oral renin-angiotensin system blockers may offer a viable option, especially in low-income nations.

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Malignant hypertension (MHT) is a severe condition necessitating early intervention.
  • Advances in antihypertensive agents have improved MHT management.
  • Lack of robust clinical trials limits formal treatment guidelines for MHT.

Purpose of the Study:

  • To review the historical and pathophysiological basis of MHT.
  • To discuss current pharmacological management practices and challenges.
  • To explore potential improvements in MHT treatment strategies.

Main Methods:

  • Literature review of historical data on MHT.
  • Analysis of pathophysiological mechanisms underlying MHT.
  • Synthesis of current evidence on pharmacological interventions for MHT.

Main Results:

  • Current consensus favors early intravenous antihypertensive therapy for MHT.
  • Oral renin-angiotensin system blockers show promise for improved MHT management.
  • MHT remains prevalent in low-income countries, highlighting treatment accessibility needs.

Conclusions:

  • Early recognition and treatment are critical for managing MHT.
  • Oral renin-angiotensin system blockers represent a potential advancement in MHT pharmacotherapy.
  • Accessible and effective MHT treatment options are crucial, particularly in resource-limited settings.

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