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Neonatal jaundice, attention deficit hyperactivity disorder and familial effects: A Swedish register study with

Isabelle Le Ray1,2, Chen Wang2, Catarina Almqvist2,3

  • 1Department of Neonatal Intensive Care, Strasbourg University Hospital, France.

Acta Paediatrica (Oslo, Norway : 1992)
|July 11, 2020
PubMed

Insights

Neonatal jaundice does not appear to independently increase the risk for attention deficit hyperactivity disorder (ADHD). Familial factors, like genetics, likely explain the observed association between jaundice and ADHD.

Area of Science:

  • Pediatrics
  • Genetics
  • Neurodevelopmental Disorders

Background:

  • Neonatal jaundice is linked to an increased risk of attention deficit hyperactivity disorder (ADHD).
  • The influence of genetic and familial factors on this association remains unclear.

Purpose of the Study:

  • To investigate the association between neonatal jaundice and ADHD.
  • To determine if familial factors mediate the relationship between neonatal jaundice and ADHD.

Main Methods:

  • A large Swedish population-based study included over 814,000 singleton births.
  • Sibling analyses were conducted to control for shared genetic and environmental factors.
  • Hazard ratios were calculated adjusting for various clinical and demographic variables.

Main Results:

  • A population-level analysis showed a modest increased risk of ADHD in children treated for neonatal jaundice (aHR: 1.13).
  • However, sibling comparison analyses revealed no clear association between neonatal jaundice and ADHD (aHR: 1.03).

Conclusions:

  • The study found no independent association between neonatal jaundice and ADHD within siblings.
  • The results suggest that shared familial factors, such as genetics and lifestyle, likely account for the observed association.
Abstract

Keywords:
attention deficit hyperactivity disorderneonatal jaundiceregister studysiblings

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