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Potential Causes and Consequences of Gastrointestinal Disorders during a SARS-CoV-2 Infection

François Trottein1, Harry Sokol2

  • 1Centre d'Infection et d'Immunité de Lille, INSERM U1019, CNRS UMR 9017, University of Lille, CHU Lille-Institut Pasteur de Lille, 59000 Lille, France.

Cell Reports
|July 11, 2020
PubMed

Insights

This review explores gastrointestinal disorders in COVID-19 patients, examining potential causes and impacts. Targeting gut dysbiosis may offer a new strategy for controlling this severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Area of Science:

  • Virology
  • Gastroenterology
  • Microbiology

Background:

  • Coronaviruses, including SARS-CoV-2, cause severe acute respiratory syndrome and the COVID-19 pandemic.
  • Gastrointestinal disorders are frequently observed in COVID-19 patients, sometimes preceding respiratory symptoms.

Purpose of the Study:

  • To review gastrointestinal disorders in COVID-19 patients.
  • To propose mechanisms for gut symptom development.
  • To discuss the impact of gut issues on disease outcome and the role of gut microbiota.

Main Methods:

  • Literature review of clinical studies on COVID-19 patients.
  • Analysis of hypothetical mechanisms for gastrointestinal manifestations.
  • Discussion of the gut microbiota's role in viral respiratory infections.

Main Results:

  • Gastrointestinal symptoms are a significant feature of COVID-19.
  • Gut dysbiosis may play a role in the pathogenesis of COVID-19.
  • Potential therapeutic strategies targeting the gut microbiota are proposed.

Conclusions:

  • Understanding the link between COVID-19 and gastrointestinal disorders is crucial.
  • Modulating the gut microbiota could be a novel therapeutic approach for COVID-19.
  • Further research is needed to elucidate the precise mechanisms and therapeutic potential.
Keywords:
COVID-19SARS-CoV-2disease outcomesgastrointestinal symptomsgut microbiotamicrobial dysbiosis

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