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Updated: Dec 15, 2025

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Human Virus Transcriptional Regulators.

Xing Liu1, Ted Hong2, Sreeja Parameswaran3

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This summary is machine-generated.

This study catalogs 419 viral transcriptional regulators (vTRs) from 20 virus families, revealing their targets and roles in human diseases. This resource aids virology and genomics research.

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Area of Science:

  • Virology
  • Genomics
  • Human Disease Genetics

Background:

  • Viral genomes encode transcriptional regulators (vTRs) that modulate viral and host gene expression.
  • A comprehensive annotation of human vTRs is currently lacking, hindering understanding of their functions and disease relevance.

Purpose of the Study:

  • To create a comprehensive catalog of human viral transcriptional regulators (vTRs).
  • To characterize the cellular targets and pathways affected by vTRs.
  • To elucidate the role of vTRs in the pathogenesis of human diseases.

Main Methods:

  • Compilation of a catalog of 419 vTRs from 20 distinct virus families.
  • Bioinformatic analysis to identify shared and unique cellular genes, proteins, and pathways targeted by vTRs.

Main Results:

  • A catalog of 419 vTRs from 20 virus families was established.
  • Characterization of cellular targets and pathways modulated by specific vTRs was performed.
  • Insights into the involvement of vTRs in human disease pathogenesis were gained.

Conclusions:

  • The developed catalog serves as a valuable resource for virology, genomics, and human disease genetics.
  • Understanding vTRs is crucial for deciphering viral mechanisms and their impact on human health.