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Updated: Dec 15, 2025

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

Published on: January 10, 2018

Cell Lineage-Based Stratification for Glioblastoma.

Zilai Wang¹, Daochun Sun¹, Yu-Jung Chen²

¹Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

|July 11, 2020

Summary

Glioblastoma subtypes are linked to cell lineage, not just mutations. The oligodendrocyte subtype needs ERBB3 and shows unique treatment responses, aiding future brain tumor classification.

Keywords:

Erbb3 GBM PDX cell of origin glioblastoma molecular classification molecular subtype mouse model neural stem cell oligodendrocyte lineage cell

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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

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Published on: September 25, 2012

Area of Science:

Neuro-oncology
Cancer genomics
Developmental biology

Background:

Glioblastoma is a major adult brain cancer.
Current molecular subtypes lack clear functional relevance.
Tumor origin and cell lineage may influence glioblastoma characteristics.

Purpose of the Study:

To identify functional glioblastoma subtypes based on cell lineage.
To investigate the role of cell of origin in glioblastoma development.
To characterize therapeutic sensitivities of lineage-defined subtypes.

Main Methods:

Analysis of transcriptional profiles in mouse models and human glioblastomas.
Development and characterization of patient-derived xenografts.
Functional studies on ERBB3 in specific glioblastoma subtypes.

Main Results:

Identified distinct transcriptional profiles in human glioblastoma corresponding to cell lineage.
Established patient-derived xenografts with conserved subtype-discriminating properties.
The oligodendrocyte lineage-associated subtype requires functional ERBB3 and exhibits unique therapeutic vulnerabilities.

Conclusions:

Cell lineage is a critical determinant of glioblastoma biology, independent of driver mutations.
A methodology for functional glioblastoma classification based on lineage is proposed.
Findings offer insights into targeted therapies for specific glioblastoma subtypes.