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Updated: Dec 15, 2025
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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
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Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study.
Patrizia Pochetti1, Danila Azzolina2, Beatrice Ragnoli1,2
1Respiratory Unit, Sant' Andrea Hospital, 13100 Vercelli, Italy.
Summary
Continuous Positive Airway Pressure (CPAP) therapy improved kidney function in obstructive sleep apnea (OSA) patients short-term, but long-term benefits were not significant, possibly due to compliance issues and aging.
Area of Science:
- Nephrology
- Pulmonology
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) is linked to declining kidney function.
- Continuous Positive Airway Pressure (CPAP) may preserve renal health in OSA patients.
Purpose of the Study:
- To assess long-term kidney function changes in OSA patients under different Positive Airway Pressure (PAP) strategies.
- To evaluate comorbidities and 10-year survival rates in relation to PAP treatment.
Main Methods:
- Retrospective, observational, single-center cohort study of 40 OSA patients.
- Measured serum creatinine and estimated Glomerular Filtration Rate (eGFR) at baseline, 3, and 8 years.
- Analyzed survival using Kaplan-Meier curves and log-rank tests.
Main Results:
- Fixed CPAP significantly reduced creatinine levels after 3 years (p=0.006).
- Long-term benefits of CPAP on renal function were not statistically significant (p=0.060).
- Progressive renal decline observed, particularly in patients using non-fixed PAP treatments.
Conclusions:
- Fixed CPAP offers short-term renal improvement in OSA patients.
- Long-term efficacy may be limited by patient compliance and aging.
- Further research is needed to optimize long-term PAP therapy for renal protection in OSA.
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