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Updated: Dec 15, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
[Generalized arterial calcification in childhood: A case report]
Nagore Arbide Del Río1, Jon Danel Solano Iturri1, María García Barcina2
1Servicio de Anatomía Patológica, Hospital Universitario Basurto, Bilbao, Vizcaya, España.
Arterial calcification of infancy is a rare genetic disorder causing severe arterial calcification in newborns. This case report details clinical and pathological findings, offering an updated genetic diagnosis for this condition.
Area of Science:
- Genetics
- Pathology
- Pediatrics
Background:
- Arterial calcification of infancy (ACI) is a rare, autosomal recessive disorder.
- It presents with extensive calcification of the internal elastic lamina and intimal thickening in arteries.
- ACI has an extremely poor prognosis.
Observation:
- A newborn necropsy case is presented with hydrops and widespread cyanosis.
- Internal examination revealed heart enlargement.
- Occlusive calcification of arteries was identified as the cause.
Findings:
- Correlation of clinical and pathological features of ACI.
- Detailed pathological examination of arterial calcification.
- Updated genetic diagnostic information for ACI.
Implications:
- Enhances understanding of ACI's clinical and pathological spectrum.
- Provides crucial information for genetic diagnosis and counseling.
- Highlights the severe impact of ACI on cardiovascular health in neonates.
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