Au nanoparticles modified CuO nanowireelectrode based non-enzymatic glucose detection with improved linearity

Area of Science:

• Electrochemistry
• Nanomaterials Science
• Biosensing

Background:

• Non-enzymatic glucose detection is crucial for diabetes management.
• Developing sensitive and reliable glucose sensors remains a significant challenge.
• Nanomaterials offer unique properties for enhanced electrochemical sensing applications.

Purpose of the Study:

• To develop a highly sensitive and reliable non-enzymatic glucose sensor.
• To explore the use of gold nanoparticle (GNP) modified copper oxide nanowires (CuO NWs) for glucose detection.
• To investigate the sensor's performance across a wide range of glucose concentrations and its stability under mechanical stress.

Main Methods:

• Fabrication of CuO NWs on copper foil via chemical etching and heat treatment.
• Deposition of GNPs onto CuO NWs to enhance surface area and catalytic activity.
• Electrochemical characterization using techniques such as cyclic voltammetry and amperometry.
• Surface morphology analysis using XRD, XPS, FE-SEM, and HR-TEM.

Main Results:

• The GNP-modified CuO NWs electrode exhibited high sensitivity (1591.44 µA mM⁻¹ cm⁻²) and a wide linear range (up to 44.36 mM).
• The sensor successfully detected low glucose concentrations (0.3 µM) and high hyperglycemia levels (~806.5454 mg/dl).
• The electrode demonstrated good stability and accuracy in detecting blood glucose levels and maintained functionality after multiple bending cycles.

Conclusions:

• The proposed GNP-modified CuO NWs electrode is a promising platform for non-enzymatic glucose sensing.
• The sensor offers excellent sensitivity, a broad detection range, and robustness for practical applications.
• This technology has potential for real-time monitoring of glucose levels in biological fluids and for wearable electronics.