Related Experiment Video

Updated: Dec 15, 2025

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.8K

Predictive Value of the Age-Adjusted Charlson Comorbidity Index for Outcomes After Hepatic Resection of

Hiroji Shinkawa1, Shogo Tanaka2, Shigekazu Takemura2

  • 1Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan. m1297198@msic.med.osaka-cu.ac.jp.

World Journal of Surgery
|July 12, 2020
PubMed

Insights

The age-adjusted Charlson comorbidity index (ACCI) significantly impacts outcomes for hepatocellular carcinoma (HCC) patients undergoing liver resection. Higher ACCI scores correlate with increased complications and poorer survival, guiding treatment strategies.

Area of Science:

  • Hepatobiliary Surgery
  • Oncology
  • Comorbidity Assessment

Background:

  • Hepatocellular carcinoma (HCC) is a primary liver cancer with significant global impact.
  • Hepatic resection is a curative treatment option for eligible HCC patients.
  • Assessing patient comorbidities is crucial for predicting surgical outcomes.

Purpose of the Study:

  • To evaluate the predictive value of the age-adjusted Charlson comorbidity index (ACCI) on outcomes following hepatic resection for HCC.
  • To determine the association between ACCI scores and postoperative complications, overall survival, and treatment strategies in HCC patients.

Main Methods:

  • Retrospective analysis of 763 patients who underwent hepatic resection for HCC.
  • Categorization of ACCI scores into three groups: ACCI ≤ 5, ACCI = 6, and ACCI ≥ 7.
  • Multivariate analysis to assess the impact of ACCI on postoperative complications and overall survival.

Main Results:

  • Higher ACCI scores (≥ 7) were significantly associated with increased odds of postoperative complications (OR 4.15, p < 0.001) and reduced overall survival (HR 2.45, p < 0.001).
  • Patients with ACCI = 6 showed a trend towards increased complications (OR 0.71, p = 0.41) and significantly reduced survival (HR 1.52, p = 0.023).
  • Higher ACCI scores correlated with a shift from surgical resection to palliative therapy for HCC recurrence.

Conclusions:

  • The age-adjusted Charlson comorbidity index is a valuable tool for predicting both short-term and long-term outcomes in HCC patients undergoing hepatic resection.
  • ACCI stratification can aid clinicians in developing personalized treatment strategies for HCC patients with varying comorbidity burdens.
  • These findings underscore the importance of comorbidity assessment in optimizing surgical decision-making and patient management for HCC.
Abstract

More Related Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

562
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.8K

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
568
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
108