Related Experiment Video

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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Cirrhotic Cardiomyopathy

Ki Tae Yoon1,2, Hongqun Liu1, Samuel S Lee3

  • 1Liver Unit, University Calgary Cumming School of Medicine, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada.

Current Gastroenterology Reports
|July 12, 2020
PubMed

Insights

Cirrhotic cardiomyopathy, a heart dysfunction in cirrhosis patients, stems from inflammation and altered cardiomyocyte function. Current management strategies require further investigation for optimal patient outcomes.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Pathophysiology

Background:

  • Cirrhotic cardiomyopathy is characterized by depressed cardiac function in individuals with cirrhosis.
  • Understanding its historical context, pathogenesis, and clinical significance is crucial.

Purpose of the Study:

  • To review the historical background, pathophysiology, pathogenesis, diagnostic criteria, clinical relevance, and management of cirrhotic cardiomyopathy.
  • To highlight recent advancements and identify areas needing further research.

Main Methods:

  • Literature review of cirrhotic cardiomyopathy.
  • Analysis of pathogenesis, diagnostic criteria, and management strategies.

Main Results:

  • Pathogenesis involves an inflammatory phenotype, gut bacterial translocation, endotoxemia, and altered cardiomyocyte function.
  • New echocardiographic criteria, including global longitudinal strain and diastolic dysfunction indices, are proposed for diagnosis.
  • Cardiac dysfunction contributes to hepatorenal syndrome and increased mortality in cirrhotic patients undergoing surgery or transplantation.

Conclusions:

  • Cirrhotic cardiomyopathy is a significant clinical syndrome in advanced cirrhosis.
  • No specific treatment is established; beta-adrenergic blockade and supportive care are proposed but require further study.
  • Optimal management remains unclear, necessitating further research.
Abstract

Keywords:
Beta-blockerCardiac functionCirrhotic cardiomyopathyCytokinesLiver transplantationTroponin

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