Melanopsin for Time-Controlling Activation of Astrocyte -Neuron Networks

Melanopsin, a mammalian G-protein-coupled photopigment, is a novel optical tool which enables studying astrocyte-neuron networks. Here, we describe the required guidelines to take advantage of this promising optical tool for functional neuron-glia studies. The selective expression of melanopsin in astrocytes allows triggering astrocytic Ca²⁺ signaling, changes in synaptic transmission, and modifying behavioral responses.