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Related Experiment Videos

[HMPAO-SPECT in cerebral seizures].

F Grünwald1, H Durwen, P Bülau

  • 1Institut für klinische und experimentelle Nuklearmedizin, Universität Bonn, BRD.

Nuklearmedizin. Nuclear Medicine
|December 1, 1988
PubMed
Summary
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Hexamethylpropylene amine oxime single-photon emission computed tomography (HMPAO-SPECT) can help diagnose epilepsy. This study found increased cerebral blood flow during epileptic seizures but not psychogenic seizures, aiding differential diagnosis.

Area of Science:

  • Neurology
  • Nuclear Medicine
  • Medical Imaging

Background:

  • Differentiating psychogenic seizures from epileptic seizures is clinically challenging.
  • Regional cerebral blood flow (rCBF) changes may help distinguish seizure types.

Purpose of the Study:

  • To evaluate the utility of Hexamethylpropylene amine oxime single-photon emission computed tomography (HMPAO-SPECT) in differentiating psychogenic seizures from epileptic seizures.
  • To assess changes in rCBF during seizures using HMPAO-SPECT.

Main Methods:

  • HMPAO-SPECT was performed in 12 patients (9 with suspected psychogenic seizures, 3 with proven epileptic seizures) before and during seizures.
  • Regional cerebral blood flow was analyzed based on HMPAO uptake patterns.

Main Results:

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  • Patients with proven epilepsy showed markedly increased circumscribed rCBF during seizures.
  • Patients with psychogenic seizures exhibited no or only slight changes in rCBF.
  • Interictal findings in epilepsy patients were sometimes normal.

Conclusions:

  • HMPAO-SPECT can identify increased rCBF during epileptic seizures, aiding in their diagnosis.
  • HMPAO-SPECT offers a diagnostic advantage for seizures due to tracer injection during the event, unlike PET.
  • This technique can help differentiate epileptic from psychogenic seizures.