Related Experiment Video
Updated: Dec 15, 2025
13:02
The Terroir Concept Interpreted through Grape Berry Metabolomics and Transcriptomics
Published on: October 5, 2016
10.8K
Exploring potential coformers for oxyresveratrol using principal component analysis
Passaporn Ouiyangkul1, Vimon Tantishaiyakul2, Namon Hirun3
1Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai 90112, Thailand.
International Journal of Pharmaceutics
|July 12, 2020
Summary
Oxyresveratrol (OXY) cocrystals with nicotinamide (NCT) and proline (PRO) were successfully formed, significantly enhancing OXY
Area of Science:
- Pharmaceutical Science
- Materials Science
- Chemical Engineering
Background:
- Oxyresveratrol (OXY) has limited pharmaceutical applications due to poor solubility and bioavailability.
- Cocrystal formation is a promising strategy to enhance the solubility of poorly soluble active pharmaceutical ingredients.
Purpose of the Study:
- To select suitable coformers for Oxyresveratrol (OXY) using principal component analysis (PCA).
- To prepare and characterize OXY cocrystals with selected coformers.
- To evaluate the impact of cocrystal formation on OXY's solubility and dissolution properties.
Main Methods:
- Principal component analysis (PCA) was used to screen coformers based on physicochemical properties.
- Cocrystals were prepared using the liquid-assisted grinding method.
- Cocrystals were characterized using thermal analysis, X-ray diffraction, FTIR, and Raman spectroscopy.
Main Results:
- PCA identified nicotinamide (NCT) and proline (PRO) as suitable coformers for OXY.
- OXY-NCT and OXY-PRO cocrystals were successfully synthesized, exhibiting distinct thermal and diffraction patterns compared to OXY.
- Spectroscopic analysis confirmed specific interactions (hydrogen bonding and π-π interactions) involved in cocrystal formation.
- Both OXY-NCT and OXY-PRO cocrystals demonstrated significantly improved solubility and dissolution rates compared to OXY alone.
Conclusions:
- PCA is an effective tool for coformer selection in cocrystal development.
- Cocrystal formation with NCT and PRO successfully enhanced OXY's solubility and dissolution.
- These findings suggest potential pharmaceutical applications for OXY cocrystals.
Related Concept Videos
01:15Carboxylic Acid Derivatives: Overview
5.0K
Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:
5.0K
02:29Conformations of Cycloalkanes
13.8K
Adolf von Baeyer attempted to explain the instabilities of small and large cycloalkane rings using the concept of angle strain — the strain caused by the deviation of bond angles from the ideal 109.5° tetrahedral value for sp3 hybridized carbons. However, while cyclopropane and cyclobutane are strained, as expected from their highly compressed bond angles, cyclopentane is more strained than predicted, and cyclohexane is virtually strain-free. Hence, Baeyer’s theory that...
13.8K
00:59Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
234
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
234
01:12Analysis of Population Pharmacokinetic Data
594
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
594
01:08Vector Algebra: Method of Components
18.5K
It is cumbersome to find the magnitudes of vectors using the parallelogram rule or using the graphical method to perform mathematical operations like addition, subtraction, and multiplication. There are two ways to circumvent this algebraic complexity. One way is to draw the vectors to scale, as in navigation, and read approximate vector lengths and angles (directions) from the graphs. The other way is to use the method of components.
In many applications, the magnitudes and directions of...
In many applications, the magnitudes and directions of...
18.5K
02:24Predicting Reaction Outcomes
9.7K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
9.7K