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Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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Exploring CYP2J2: lipid mediators, inhibitors and therapeutic implications

Marco Sisignano1, Dieter Steinhilber2, Michael J Parnham3

  • 1Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, University Hospital of Goethe-University, 60590 Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch Translational Medicine & Pharmacology TMP, 60596 Frankfurt am Main, Germany.

Drug Discovery Today
|July 12, 2020
PubMed
Summary

Cytochrome P450 2J2 (CYP2J2) metabolizes polyunsaturated fatty acids into epoxylipids with diverse biological roles. Targeting CYP2J2 offers potential therapeutic strategies for conditions like chronic pain and cancer.

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