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Disseminated cryptococcosis with cutaneous manifestation
Matthew M Johnson1, Kiran Gajurel2
1Carolinas Pathology Group, Charlotte, NC, USA.
Summary
Cutaneous cryptococcosis is a rare fungal infection often indicating widespread disease. This case highlights forehead nodular lesions in a kidney transplant recipient post-rejection, emphasizing disseminated cryptococcosis.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Transplantation Immunology
Background:
- Cutaneous manifestations of fungal infections are infrequent.
- Disseminated fungal infections can present with diverse dermatological signs.
- Kidney transplant recipients are immunocompromised, increasing susceptibility to opportunistic infections.
Observation:
- A kidney transplant recipient developed nodular lesions on the forehead.
- The patient had recently experienced a period of acute cellular rejection.
- These skin findings were indicative of a disseminated infection.
Findings:
- The forehead lesions were diagnosed as cutaneous cryptococcosis.
- This represented a disseminated Cryptococcus neoformans infection.
- The presentation occurred in the context of immunosuppression and rejection.
Implications:
- Cutaneous cryptococcosis can be an early sign of disseminated disease in transplant patients.
- Prompt diagnosis and treatment are crucial for managing systemic fungal infections post-transplantation.
- This case underscores the importance of dermatological surveillance in immunocompromised individuals.
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