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Ticagrelor monotherapy in patients undergoing percutaneous coronary intervention for bifurcation lesions
Raffaele Piccolo1, Giovanni Esposito1
1Division of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Insights
Ticagrelor monotherapy following brief aspirin use is a safe and effective strategy for patients after percutaneous coronary intervention, including those with complex bifurcation lesions.
Area of Science:
- Cardiology
- Interventional Cardiology
- Pharmacology
Background:
- Percutaneous coronary intervention (PCI) is a common procedure for coronary artery disease.
- Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is standard post-PCI, but increases bleeding risk.
- Aspirin-free strategies, such as ticagrelor monotherapy, are being investigated to mitigate bleeding complications.
Abstract:
Ticagrelor monotherapy after a short course of aspirin is emerging as the predominant aspirin-free strategy among patients undergoing percutaneous coronary intervention. In patients included in the GLOBAL-LEADERS trial, the treatment effect of the experimental (dual antiplatelet therapy with aspirin and ticagrelor for 1 month followed by ticagrelor monotherapy) versus control strategy remained consistent irrespective of the presence or absence of coronary bifurcation. Ticagrelor monotherapy represents a safe and effective antiplatelet strategy for the treatment of patients who undergo percutaneous coronary intervention of bifurcation lesions.
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