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Updated: Dec 15, 2025

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
Published on: October 8, 2018
A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention
Stefan H Oehlers1,2, Elinor Hortle1,2, Kristina M Cook3
1The University of Sydney, Tuberculosis Research Program at the Centenary Institute, Camperdown, NSW, Australia.
Abstract:
Comorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective hypoxia-inducible factor-1α activation as an example of a host-directed therapy. This platform is a new paradigm for the zebrafish-M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies. Comment on: https://doi.org/10.1111/febs.15433.
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