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Clinical Characteristics and Outcomes of 74 Patients With Severe or Critical COVID-19

Junli Li1, Ge Xu2, Heping Yu3

  • 1Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

The American Journal of the Medical Sciences
|July 13, 2020
PubMed

Insights

Elderly patients with comorbidities face higher risks of severe COVID-19 and death. Early comprehensive treatment for patients with poor blood gas and coagulation indicators can improve prognosis and reduce mortality.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Epidemiology

Background:

  • The COVID-19 pandemic poses a significant global health concern.
  • Understanding clinical characteristics of severe and critical cases is crucial for patient outcomes.

Purpose of the Study:

  • To clarify the clinical characteristics differentiating recovery from death in severe or critical COVID-19 patients.
  • To identify predictors of mortality in severe COVID-19.

Main Methods:

  • Retrospective single-center study of 74 severe or critical COVID-19 patients.
  • Data collected from January 25th to February 26th, 2020.
  • Comparison of clinical and laboratory data between recovery and death groups.

Main Results:

  • The death group was older and had higher incidences of hypertension, coronary disease, and dyspnea.
  • Elevated lactate dehydrogenase, creatine kinase, myoglobin, brain natriuretic peptide, and D-dimer were observed in the death group.
  • Lower PaO2:FiO2 ratio, minimum SpO2, and higher rates of mechanical ventilation and ECMO were associated with mortality.

Conclusions:

  • Elderly patients with comorbidities are at increased risk for severe COVID-19 and mortality.
  • Low blood gas index and impaired coagulation at admission predict high mortality.
  • Prompt comprehensive treatment is essential to improve prognosis and reduce mortality in high-risk patients.
Abstract

Keywords:
COVID-19Clinical featuresCoronavirusSARS-CoV-2

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