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Updated: Dec 15, 2025

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
Daratumumab for pure red cell aplasia post ABO incompatible allogeneic hematopoietic stem cell transplant for
Preethi Jeyaraman1, Pronamee Borah1, Priyanka Rajput1
1Division of Hematology and Bone Marrow Transplant, Max Super-speciality Hospital, India.
Abstract:
Pure red cell aplasia is a known complication after ABO incompatible stem cell transplant. Due to rarity of disease, no established treatment guidelines are available for PRCA. Daratumumab is a monoclonal antibody against CD38 expressed by plasma cells. In this report we present our experience of successfully managing a patient of post-transplant PRCA with daratumumab. Our patient had failed multiple lines of therapy prior to receiving daratumumab. Response was seen after the 3rd weekly dose of daratumumab.
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