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Related Experiment Video

Updated: Dec 15, 2025

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
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Function-based dementia severity assessment for vascular cognitive impairment.

Chao-Hsien Hung1, Guang-Uei Hung2, Cheng-Yu Wei3

  • 1Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|July 13, 2020
PubMed
Summary
This summary is machine-generated.

A new History-based Artificial Intelligent Activities of Daily Living (HAI-ADL) questionnaire effectively diagnoses unimpaired ADL in vascular cognitive impairment with no dementia (VCIND). The HAI-ADL also predicts progression to vascular dementia (VaD).

Keywords:
Activities of daily livingCerebrovascular diseaseDementiaVascular cognitive impairment

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Area of Science:

  • Neurology
  • Gerontology
  • Cognitive Science

Background:

  • Unimpaired activities of daily living (ADL) are crucial for diagnosing normal cognition and mild cognitive impairment.
  • Diagnosing ADL is challenging in patients with comorbid motor dysfunction, particularly in vascular cognitive impairment with no dementia (VCIND).

Purpose of the Study:

  • To introduce and validate a novel History-based Artificial Intelligent ADL (HAI-ADL) questionnaire for operational diagnosis of unimpaired ADL in VCIND.
  • To assess the diagnostic and predictive capabilities of HAI-ADL compared to existing tools.

Main Methods:

  • A retrospective cohort study involving 596 individuals with cerebrovascular disease, including normal cognition (CVDNC), VCIND, and vascular dementia (VaD).
  • Comparison of cutoff scores for unimpaired ADL between HAI-ADL and other tools (CDR-SB, IADL, BI, CASI).
  • Longitudinal analysis of progression rates from CVDNC/VCIND to VaD based on HAI-ADL scores.

Main Results:

  • The HAI-ADL demonstrated effective differentiation of cognitive impairment stages, with a cutoff score of 8.5 for unimpaired ADL in VCIND.
  • HAI-ADL showed the highest correlation with CDR-SB and the CDR staging system.
  • Individuals with HAI-ADL scores > 8.5 exhibited significantly higher odds of progression to VaD (ORs ranging from 2.77 to 3.75).

Conclusions:

  • The HAI-ADL questionnaire provides an operational definition for unimpaired ADL, essential for VCIND diagnosis.
  • Long-term follow-up confirmed the HAI-ADL's predictive value for dementia progression in patients with cerebrovascular disease.