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Gaining insights on immune responses to the novel coronavirus, COVID-19 and therapeutic challenges

Mahsa Hajivalili1, Maryam Hosseini2, Mostafa Haji-Fatahaliha3

  • 1Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Life Sciences
|July 13, 2020
PubMed

Insights

This review examines the immune system's response to SARS-CoV-2, the virus causing COVID-19. It explores immune interactions, therapeutic strategies, and vaccine candidates for future prevention and treatment.

Area of Science:

  • Immunology
  • Virology
  • Infectious Diseases

Background:

  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) rapidly spread globally, overwhelming healthcare systems.
  • The novel coronavirus disease (COVID-19) necessitated urgent research into its mechanisms and control.
  • Understanding the host-pathogen interaction is critical for developing effective countermeasures.

Purpose of the Study:

  • To review the immunological response to SARS-CoV-2 infection.
  • To elucidate the consequences of immune system interactions with the virus.
  • To summarize current therapeutic approaches and potential vaccine candidates for COVID-19.

Main Methods:

  • Literature review of immunological and virological studies on SARS-CoV-2.
  • Analysis of immune system behavior during SARS-CoV-2 infection.
  • Compilation of data on therapeutic interventions and vaccine development.

Main Results:

  • The immune system exhibits complex responses to SARS-CoV-2, with varying outcomes.
  • Immune dysregulation can contribute to severe COVID-19 pathogenesis.
  • Several therapeutic strategies and vaccine candidates show promise in preclinical and clinical studies.

Conclusions:

  • A comprehensive understanding of the immune response to SARS-CoV-2 is vital for combating COVID-19.
  • Targeting immune pathways and developing effective vaccines are key strategies.
  • Continued research is essential for refining treatments and preventive measures against SARS-CoV-2.
Keywords:
CVID-19Cytokine stormImmune responseInflammation

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