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Vada maker's dystonia - A new task-specific focal dystonia

Ajith Cherian1, K P Divya1

  • 1Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, PIN-695011, India.

Parkinsonism & Related Disorders
|July 13, 2020
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Botulinum toxin therapyInvoluntary movementsMotor taskOveruse syndromesTask-specific dystonia

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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