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Ischemic Heart Disease: Overview

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...

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Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

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Altered lncRNAs Transcriptomic Profiles in Atherosclerosis-Induced Ischemic Stroke.

Wenchen Ruan^1,2, Jiayang Wu², Jingjing Su³

¹Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, People's Republic of China.

Cellular and Molecular Neurobiology

|July 13, 2020

Summary

Long non-coding RNAs (lncRNAs) are implicated in atherosclerosis-induced ischemic stroke (AIIS). This study identified key lncRNAs and mRNAs involved in ubiquitination pathways, offering new insights into AIIS pathogenesis.

Keywords:

Atherosclerosis Ischemic stroke LncRNA Transcriptome

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Published on: June 22, 2010

Area of Science:

Molecular Biology
Genomics
Neuroscience

Background:

Long non-coding RNAs (lncRNAs) are epigenetic regulators involved in central nervous system diseases.
The role of lncRNAs in atherosclerosis-induced ischemic stroke (AIIS) remains largely uncharacterized.

Purpose of the Study:

To identify differentially expressed lncRNAs (delncRNAs) in AIIS patients.
To elucidate the regulatory mechanisms and biological functions of these delncRNAs in AIIS pathophysiology.
To construct a lncRNA-mRNA interaction network for AIIS.

Main Methods:

Microarray analysis of whole blood RNA from 10 AIIS patients and 10 healthy controls.
Gene Ontology (GO) and KEGG pathway analysis to explore delncRNA functions.
Analysis of THP-1 cells stimulated with ox-LDL to identify selective lncRNAs.
Co-expression analysis to build a lncRNA-mRNA interaction network.

Main Results:

Identified 180 delncRNAs (44 upregulated, 136 downregulated) and 218 differentially expressed mRNAs (demRNAs).
Lnc-SCARNA8 and lnc-SNRPN-2 were the most significantly elevated and decreased lncRNAs, respectively.
delncRNAs are significantly enriched in ubiquitination-mediated protein degradation pathways.
The lncRNA-mRNA network highlighted VPS13B and BLVRB as key regulated genes.

Conclusions:

Ubiquitination-mediated protein degradation pathways, along with VPS13B and BLVRB, are fundamentally involved in the pathological processes of AIIS.
This study provides novel molecular targets for understanding and potentially treating AIIS.