Paediatricians' practices and knowledge of corticosteroids: A national survey

Opal Sekler1, Anat Segev-Becker2, Hagar Interator2,3

  • 1Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Insights

Paediatricians show gaps in knowledge regarding corticosteroid tapering and stress dosing, despite extensive experience. Continued medical education (CME) is recommended to improve patient care and management of corticosteroid therapy.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Pharmacy
  • Medical Education

Background:

  • Corticosteroids are widely used in pediatric care, necessitating a thorough understanding of their prescription and management.
  • Gaps in knowledge regarding corticosteroid use can lead to suboptimal patient outcomes and potentially life-threatening situations.

Purpose of the Study:

  • To assess the current corticosteroid prescription patterns among pediatricians.
  • To evaluate pediatricians' knowledge of critical aspects of corticosteroid therapy, including tapering and stress dosing.
  • To identify factors associated with better knowledge and to determine the need for further education.

Main Methods:

  • A cross-sectional, web-based survey, the Paediatricians Corticosteroids Survey, was conducted.
  • The survey was distributed to Israeli pediatricians between February and July 2018.
  • Data from 349 participants were analyzed, including experience, prescription rates, and knowledge assessment.

Main Results:

  • While 55% of pediatricians prescribed corticosteroids to over 10% of their patients, significant knowledge gaps were observed in areas like steroid tapering (4.1% unsure) and stress dosing (8.2% unsure of meaning, 10.1% unsure when required).
  • Higher knowledge scores were associated with specialized training in pediatric endocrinology, subspecialty practice, and medical studies within Israel.
  • A strong majority (96.2%) expressed interest in continued medical education (CME) sessions focused on corticosteroids.

Conclusions:

  • Despite considerable clinical experience, pediatricians exhibit deficits in knowledge concerning critical corticosteroid management, particularly in emergency scenarios.
  • Targeted, corticosteroid-focused CME programs are essential to enhance pediatricians' expertise and improve the management of pediatric patients on corticosteroid therapy.
Abstract

Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.4K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
155
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
149
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
133
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
620
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
115