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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Related Experiment Video

Updated: Dec 15, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

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IL17RA variations showed no associations with post-bronchiolitis asthma or lung function.

Eero Lauhkonen1, Annukka Holster1, Johanna Teräsjärvi2

  • 1Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland.

Pediatrics International : Official Journal of the Japan Pediatric Society
|July 13, 2020
PubMed
Summary

Investigated IL17RA gene variations in children hospitalized for bronchiolitis. The study found no significant association between these IL17RA variations and the development of asthma, allergies, or reduced lung function later in childhood.

Keywords:
bronchiolitischildhood asthmagenetic variationinterleukin-17 receptor Alung function

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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Area of Science:

  • Genetics and Immunology
  • Pediatric Respiratory Medicine

Background:

  • Interleukin-17A (IL-17A) and IL-17F are implicated in asthma and allergy pathogenesis.
  • Interleukin-17 receptor A (IL-17RA) is a shared receptor for IL-17A and IL-17F, encoded by the IL17RA gene.

Purpose of the Study:

  • To investigate the association between IL17RA gene variations and asthma, allergy, and lung function in children.
  • To evaluate these associations in children prospectively followed after early infancy bronchiolitis hospitalization.

Main Methods:

  • Genotyping of IL17RA polymorphisms (rs4819553, rs4819554, rs4819558) in former bronchiolitis patients.
  • Clinical outcome assessment for asthma and allergic rhinitis at school age (5-7 and 11-13 years).
  • Pulmonary function testing including impulse oscillometry and spirometry.

Main Results:

  • No significant differences in IL17RA genotype or allele frequencies between bronchiolitis cases and controls.
  • IL17RA variations showed no association with asthma or allergic rhinitis.
  • No significant association found between IL17RA variations and reduced lung function at school age.

Conclusions:

  • Studied IL17RA gene variations are not associated with severe bronchiolitis susceptibility.
  • These variations do not predict post-bronchiolitis asthma or impaired lung function in childhood.
  • Further research with larger cohorts and diverse polymorphisms is warranted.