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IL17RA variations showed no associations with post-bronchiolitis asthma or lung function.
Eero Lauhkonen1, Annukka Holster1, Johanna Teräsjärvi2
1Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland.
Summary
Investigated IL17RA gene variations in children hospitalized for bronchiolitis. The study found no significant association between these IL17RA variations and the development of asthma, allergies, or reduced lung function later in childhood.
Area of Science:
- Genetics and Immunology
- Pediatric Respiratory Medicine
Background:
- Interleukin-17A (IL-17A) and IL-17F are implicated in asthma and allergy pathogenesis.
- Interleukin-17 receptor A (IL-17RA) is a shared receptor for IL-17A and IL-17F, encoded by the IL17RA gene.
Purpose of the Study:
- To investigate the association between IL17RA gene variations and asthma, allergy, and lung function in children.
- To evaluate these associations in children prospectively followed after early infancy bronchiolitis hospitalization.
Main Methods:
- Genotyping of IL17RA polymorphisms (rs4819553, rs4819554, rs4819558) in former bronchiolitis patients.
- Clinical outcome assessment for asthma and allergic rhinitis at school age (5-7 and 11-13 years).
- Pulmonary function testing including impulse oscillometry and spirometry.
Main Results:
- No significant differences in IL17RA genotype or allele frequencies between bronchiolitis cases and controls.
- IL17RA variations showed no association with asthma or allergic rhinitis.
- No significant association found between IL17RA variations and reduced lung function at school age.
Conclusions:
- Studied IL17RA gene variations are not associated with severe bronchiolitis susceptibility.
- These variations do not predict post-bronchiolitis asthma or impaired lung function in childhood.
- Further research with larger cohorts and diverse polymorphisms is warranted.
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