Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.5K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Female neuroanatomy and its relevance to multiple sclerosis.

Multiple sclerosis and related disorders·2026
Same author

Beyond the rash: The long-term consequences of vertically and horizontally acquired measles in infants and children.

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada·2026
Same author

The many faces of the multiple sclerosis population in Canada.

Multiple sclerosis and related disorders·2026
Same author

Retinal hyper-reflective foci link retinal and cortical pathology in paediatric multiple sclerosis.

Brain : a journal of neurology·2026
Same author

Racial identity, marginalization, and depression in pediatric-onset multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Inborn errors of immunity in children with neuroinflammation.

Developmental medicine and child neurology·2026

Related Experiment Video

Updated: Dec 15, 2025

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.5K

Treatment Optimization in Multiple Sclerosis: Canadian MS Working Group Recommendations.

Mark S Freedman1, Virginia Devonshire2, Pierre Duquette3

  • 1The University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|July 14, 2020
PubMed
Summary

Canadian experts updated multiple sclerosis (MS) treatment guidelines. These recommendations cover early treatment, monitoring, and switching disease-modifying therapies for all MS types, including pediatric and aggressive forms.

Keywords:
MULTIPLE SCLEROSISRecommendationsSequencingTHERAPEUTICSTreatment optimization

More Related Videos

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

2.0K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.0K

Related Experiment Videos

Last Updated: Dec 15, 2025

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.5K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

2.0K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.0K

Area of Science:

  • Neurology
  • Immunology

Background:

  • Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Optimal management of MS requires timely and effective use of disease-modifying therapies (DMTs).

Purpose of the Study:

  • To update and provide guidance on the optimal use of DMTs for all forms of MS.
  • To offer recommendations on treatment initiation, monitoring, and modification for effective disease control.

Main Methods:

  • Consensus-based recommendations developed by the Canadian Multiple Sclerosis Working Group.
  • Review of current evidence and clinical expertise on DMTs for multiple sclerosis.

Main Results:

  • Updated guidance on early treatment initiation and monitoring of treatment response.
  • Recommendations for managing pediatric MS, progressive MS, and aggressive disease forms.
  • Considerations for newer therapies, including safety, treatment sequencing, pregnancy, biomarkers, and discontinuation of therapy.

Conclusions:

  • The updated Treatment Optimization Recommendations (TORs) provide a framework for neurologists to optimize DMT use in MS.
  • Balancing efficacy and safety is crucial, especially with advanced therapies and complex treatment sequencing.
  • These guidelines aim to improve long-term outcomes for individuals with all types of multiple sclerosis.