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A case of lip squamous cell carcinoma with a familial history of Xeroderma pigmentosum
Rami Dartaha1, Amira Yasmine Benmelouka2, Afnan W M Jobran3
1Rambam Hospital, Private Clinics, Haifa, Palestine.
Abstract:
Xeroderma pigmentosum is an orphan hereditary photosensitive human disorder that is recognized by the development of skin lesions in sun-exposed regions of the body due to severe photosensitivity. Patients with this condition have an abnormal DNA repair process due to a genetic mutation. Xeroderma pigmentosum is considered as a risk factor of cancer since the affected population may develop various cutaneous cancers including both melanoma and non-melanoma cutaneous malignancies even at a younger age than the general population. This risk concerns also asymptomatic heterozygote individuals. Here, we present a case of 46 years old man with a familial history of Xeroderma pigmentosum who developed a microscopically confirmed squamous cell carcinoma of the lip.
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