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The Prevalence of Renal Scars Among Infants Under One Year Old With a First UTI With or Without VUR in Qom, Iran,

Mohsen Akhavan Sepahi, Fateme Toloii, Shahram Arsang Jang

  • 1faculty member of Sabzevar University of Medical Sciences. hoseinil871@gmail.com.

Iranian Journal of Kidney Diseases
|July 14, 2020
PubMed

Insights

Renal scarring is common in infants with their first urinary tract infection (UTI), especially when accompanied by vesicoureteral reflux. Early screening is crucial to prevent kidney damage in children.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Infectious Diseases

Background:

  • Renal scarring can lead to chronic kidney disease.
  • Urinary tract infections (UTIs) in infants are a significant risk factor for renal scarring.
  • Vesicoureteral reflux (VUR) exacerbates the risk of renal damage following UTIs.

Purpose of the Study:

  • To determine the prevalence of renal scars in infants under one year old experiencing their first UTI in Qom, Iran.
  • To assess the association between VUR and the incidence of renal scarring in this population.

Main Methods:

  • Retrospective study analyzing medical records of 140 infants diagnosed with their first UTI.
  • Infants were divided into two groups: 70 with VUR and 70 without VUR.
  • Statistical analysis was used to compare the prevalence of renal scars between the groups.

Main Results:

  • The overall prevalence of renal scars was 32.12% among the studied infants.
  • Infants with VUR had a significantly higher prevalence of renal scars (47.1%) compared to those without VUR (17.1%) (P < .001).
  • A positive correlation was observed between higher grades of VUR and an increased rate of renal defects.

Conclusions:

  • The prevalence of renal scarring in infants with first-time UTIs in Qom is notably high.
  • Vesicoureteral reflux is a significant risk factor for developing renal scars in infants post-UTI.
  • Implementing screening protocols for susceptible children is recommended to enable early detection and prevent progressive renal damage.

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