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Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation

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EUS tissue acquisition: From A to B.

Bojan Kovacevic¹, Peter Vilmann¹

¹Gastro Unit, Division of Endoscopy, Herlev and Gentofte Hospital, Copenhagen University, Herlev, Denmark.

Endoscopic Ultrasound

|July 14, 2020

Summary

This summary is machine-generated.

Endoscopic ultrasound-guided tissue acquisition (EUS-TA) has evolved, with newer biopsy needles (FNB) offering advantages over fine-needle aspiration (FNA) for specific diagnostic needs.

Keywords:

EUS FNA fine-needle biopsy pancreas

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Area of Science:

Gastroenterology
Endoscopic Ultrasound
Interventional Endoscopy

Background:

Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is crucial for diagnosing upper gastrointestinal and mediastinal lesions.
Fine-needle aspiration (FNA) was the traditional method but has limitations in preserving tissue architecture.
Novel biopsy needles (FNB) were developed to overcome FNA's limitations.

Purpose of the Study:

To review the evolution and comparative performance of EUS-guided tissue acquisition techniques.
To evaluate the diagnostic accuracy and specimen quality of FNA versus different generations of FNB needles.
To explore emerging applications of EUS-TA in personalized medicine.

Main Methods:

Review of literature on EUS-guided tissue acquisition techniques, including FNA and FNB needles.
Comparison of diagnostic yield and specimen characteristics between FNA and FNB devices.
Discussion of advancements in EUS-TA, such as genetic profiling and organoid generation.

Main Results:

FNA and FNB needles show comparable diagnostic accuracy.
Second-generation FNB needles require fewer passes than FNA.
Third-generation FNB needles (crown-cut) are preferred for larger specimens and preserved architecture.

Conclusions:

EUS-TA techniques continue to advance, offering improved tissue acquisition.
Third-generation FNB needles provide superior histological specimens compared to FNA and earlier FNB generations.
Future applications in genetic profiling and organoid creation may further refine EUS-TA's role in personalized medicine.