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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

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Brain White Matter Correlates of Creativity in Schizophrenia: A Diffusion Tensor Imaging Study.

Agurne Sampedro¹, Javier Peña¹, Naroa Ibarretxe-Bilbao¹

¹Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain.

Frontiers in Neuroscience

|July 14, 2020

Summary

White matter integrity in the brain is linked to creative performance in individuals with schizophrenia. Specific white matter regions, particularly in the right hemisphere, are associated with figural creativity, suggesting a neural basis for creativity impairments in this population.

Keywords:

creativity divergent thinking fractional anisotropy psychosis schizophrenia white matter

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Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

The link between creativity and psychopathology, particularly schizophrenia, is a long-standing research area.
Individuals with schizophrenia often exhibit impaired creative performance, but the underlying neural mechanisms are not well understood.
Investigating brain white matter (WM) integrity may elucidate these impairments.

Purpose of the Study:

To examine the whole-brain white matter (WM) correlates of creativity dimensions in people with schizophrenia.
To identify specific WM regions associated with different aspects of creativity in this patient group.

Main Methods:

Fifty-five patients with schizophrenia underwent diffusion-weighted imaging (3T MRI) and creativity assessments (verbal and figural).
Tract-based spatial statistics (TBSS) using FMRIB Software Library (FSL) analyzed WM integrity (mean fractional anisotropy - FA).
Analyses controlled for demographic and clinical variables like sex, age, IQ, and medication.

Main Results:

Positive correlations were found between mean FA in frontal, temporal, subcortical, brain stem, and interhemispheric regions and figural originality.
Key significant clusters included the right corticospinal tract (cerebral peduncle) and the right body of the corpus callosum.
No significant correlations were observed for verbal creativity.

Conclusions:

Widespread white matter integrity is implicated in the creative performance of individuals with schizophrenia.
The identified WM regions are consistent with those linked to creativity in healthy populations and are also known to be affected in schizophrenia.
These findings suggest that white matter alterations may underlie the observed deficits in creativity in schizophrenia.