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Updated: Dec 15, 2025
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Effects of fluorinated porcine hydroxyapatite on lateral ridge augmentation: an experimental study in the canine
Yuanxiang Liu1, Chengwu Liu1, Ruoxuan Huang1
1Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology Guangzhou, China.
Purpose:
The aim of this study was to evaluate the effects of porcine hydroxyapatite (PHA) and fluorinated porcine hydroxyapatite (FPHA) applied concomitantly with collagen membranes (CMs) on bone regeneration in mandibular lateral ridge defects.
Materials And Methods:
Mandibular third premolar to second molar were extracted bilaterally in six male beagle dogs. After 8 weeks of healing, six standardized box-shaped defects were bilaterally created at the buccal aspect of the mandibles and randomly allocated in a split-mouth design to the (i) PHA, (ii) FPHA or (iii) blank group and covered with CMs. After 12 weeks, biopsies of the defects were obtained for micro-computed tomography (micro-CT) evaluation and histological analysis.
Results:
Both FPHA and PHA promoted new bone formation and showed a better ridge width maintenance capacity than the blank control treatment. The micro-CT evaluation showed that the bone volume fraction (BV/TV) in the FPHA group was significantly higher than that in the PHA group. The trabecular number (Tb.N) in the FPHA group was significantly higher than that in the blank group. Histomorphometric analysis revealed a significantly larger area and higher ratio of newly formed bone in the FPHA group than those in the PHA group. The ratio of non-mineralized tissue in the FPHA group was significantly lower than that in the PHA group. No significant difference in the amount of residual materials was found between the FPHA and PHA groups.
Conclusions:
FPHA achieved better ridge width maintenance and bone regeneration outcomes than PHA as a bone substitute in lateral ridge augmentation.
