Related Experiment Video

Updated: Dec 15, 2025

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
10:18

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

Published on: February 1, 2022

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In the eye of the storm: the right ventricle in COVID-19

John F Park1, Somanshu Banerjee1, Soban Umar1

  • 1Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Pulmonary Circulation
|July 14, 2020
PubMed

Insights

The SARS-CoV-2 virus, causing COVID-19, can impact the heart

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pulmonology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has led to significant global health issues.
  • While cardiovascular manifestations are known, the effects on the right ventricle are not well understood.
  • The right ventricle is particularly vulnerable to dysfunction during COVID-19.

Purpose of the Study:

  • To investigate the impact of SARS-CoV-2 on right ventricle function.
  • To identify potential mechanisms leading to right ventricle dysfunction in COVID-19 patients.

Main Methods:

  • This study reviews existing literature and pathophysiological mechanisms.
  • Analysis of cardiovascular presentations associated with SARS-CoV-2 infection.

Main Results:

  • Potential mechanisms for right ventricle dysfunction include increased afterload (ARDS, PE), cytokine effects, and direct cardiac injury via ACE2.
  • Right ventricle dysfunction is a significant concern in COVID-19.

Conclusions:

  • Early identification and management of right ventricle dysfunction are crucial.
  • Addressing right ventricle dysfunction may improve outcomes and reduce mortality in COVID-19 patients.

Keywords:
COVID-19acute respiratory distress syndromes (ARDSs) and acute lung injurypulmonary embolismpulmonary hypertensionright ventricle function and dysfunction

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