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Development of an appropriate simple suspension method for valganciclovir medication
Yasuyuki Masaoka1, Yoichi Kawasaki1, Ryo Kikuoka2
1Department of Pharmacy, Okayama University Hospital, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558 Japan.
Journal of Pharmaceutical Health Care and Sciences
|July 14, 2020
Summary
Preparing valganciclovir (VGC) suspensions for pediatric patients requires careful measurement. Cracking VGC tablets and using 55°C water optimizes dissolution and stability for nasogastric tube delivery.
Area of Science:
- Pharmacology
- Pharmaceutical Science
- Drug Delivery
Background:
- Valganciclovir (VGC) is crucial for preventing cytomegalovirus (CMV) infections post-transplant in adults and children.
- Pediatric VGC administration necessitates tablet pulverization for nasogastric tube delivery.
- The simple suspension method in hot water is common in Japan, but optimal conditions are unknown.
Purpose of the Study:
- To determine optimal suspension conditions for valganciclovir (VGC) tablets using the simple suspension method.
- To identify effective metering methods for preparing VGC suspensions for pediatric use.
- To assess the stability and deliverability of VGC suspensions.
Main Methods:
- Valganciclovir (VGC) tablets were suspended in water at 25°C or 55°C.
- High-performance liquid chromatography (HPLC) was used to determine VGC concentration and residual rates.
- Suspensions were tested for passage through 6, 8, and 12 Fr. gavage tubes.
Main Results:
- Cracking VGC tablet surfaces and suspending in 55°C water effectively dissolved the tablets.
- VGC suspension concentration remained stable for at least 80 minutes at room temperature and for 48 hours under cold, dark storage.
- Cracking surfaces was a more effective metering method than pulverizing tablets; minimal VGC residue was found in gavage tubes.
Conclusions:
- Optimal preparation of VGC suspensions involves cracking tablet surfaces and using 55°C water.
- The VGC suspension demonstrated good stability and deliverability through nasogastric tubes.
- Careful measurement is essential when preparing VGC solutions via the simple suspension method.
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