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Cryptococcal Choroid Plexitis and Non-Communicating Hydrocephalus
Kyle P O'Connor1, Panayiotis E Pelargos1, Camille K Milton1
1Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Abstract:
Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid barrier, serves as one potential entry point for the pathogen, disease involvement of the choroid plexus itself remains a very rare manifestation of Cryptococcus infection. In cases in which choroid plexus involvement blocks cerebrospinal fluid flow, obstructive hydrocephalus may occur. Here we report the case of a 63-year-old woman who presented with choroid plexitis causing obstructive hydrocephalus at the foramen of Monro. Endoscopic biopsy confirmed Cryptococcus neoformans, and the patient was successfully treated with amphotericin, flucytosine, and fluconazole. With proper recognition and treatment of this pathology, patients can fully recover from this condition.
Insights
Cryptococcus neoformans can infect the central nervous system, rarely affecting the choroid plexus. This case highlights successful treatment of cryptococcal choroid plexitis causing obstructive hydrocephalus.
Area of Science:
- Neurology
- Infectious Diseases
- Mycology
Background:
- Cryptococcus neoformans commonly affects the central nervous system.
- The choroid plexus is a potential entry point for C. neoformans.
- Choroid plexus involvement by C. neoformans is rare but can cause obstructive hydrocephalus.
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